Despite the development of new policies and the use of highly sensitive assays, reports of the transmission of infection to organ transplantation recipients remain uncommon but occur with sufficient frequency to suggest that current approaches to screening of donors are inadequate. The role of geographically restricted microorganisms has also increased as a consequence of travel and migration of populations. The commercialization of transplantation in some regions may also minimize the incentive to test and exclude potentially infected donors. Recent clusters of organ-associated viral transmissions illustrate the vulnerability of immunosuppressed recipients to infections due to organisms of limited native virulence for normal individuals. Many potential exposures are too common or too nonspecific to allow appropriate decision-making regarding the risk of transmission. Furthermore, in some clusters of documented transmissions (e.g. due to lymphocytic choriomeningitis, LCMV), no clear exposure or evidence of donor infection could be demonstrated even in retrospective investigation.

Donor derived infections

GROSSI, PAOLO ANTONIO;
2009-01-01

Abstract

Despite the development of new policies and the use of highly sensitive assays, reports of the transmission of infection to organ transplantation recipients remain uncommon but occur with sufficient frequency to suggest that current approaches to screening of donors are inadequate. The role of geographically restricted microorganisms has also increased as a consequence of travel and migration of populations. The commercialization of transplantation in some regions may also minimize the incentive to test and exclude potentially infected donors. Recent clusters of organ-associated viral transmissions illustrate the vulnerability of immunosuppressed recipients to infections due to organisms of limited native virulence for normal individuals. Many potential exposures are too common or too nonspecific to allow appropriate decision-making regarding the risk of transmission. Furthermore, in some clusters of documented transmissions (e.g. due to lymphocytic choriomeningitis, LCMV), no clear exposure or evidence of donor infection could be demonstrated even in retrospective investigation.
2009
Donor safety; donor testing; Infection; high-risk donor; transplantation; window period
Grossi, PAOLO ANTONIO; JAY A., Fishman
File in questo prodotto:
File Dimensione Formato  
donor derived infection in solid organ transplant recipients.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: DRM non definito
Dimensione 95.2 kB
Formato Adobe PDF
95.2 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/13039
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 79
  • ???jsp.display-item.citation.isi??? 67
social impact