Pharmacological treatment, usually by thionamides (carbimazole, methimazole, propylthiouracil) is, in addition to radioiodine therapy and thyroidectomy, one of the available therapies for Graves' hyperthyroidism. Thionamides represent the treatment of choice in pregnant women, during lactation, in children and adolescents and in preparation for radioiodine therapy or thyroidectomy. Side effects are relatively frequent but are in general mild and transient. Two main regimens are available: titration method (use of the lowest dose maintaining euthyroidism; duration: 12 - 18 months) and block-and-replace method. Neither one has clear advantages in terms of outcome but the latter method is associated with more frequent side effects. Hyperthyroidism relapses in ∼ 50% of patients, to whom ablative therapy should be offered. © 2005 Ashley Publications Ltd.

An update on the pharmacological management of hyperthyroidism due to Graves' disease

BARTALENA, LUIGI;TANDA, MARIA LAURA PIERA;PIANTANIDA, ELIANA ANGELA ROSA;LAI, ADRIANA;
2005-01-01

Abstract

Pharmacological treatment, usually by thionamides (carbimazole, methimazole, propylthiouracil) is, in addition to radioiodine therapy and thyroidectomy, one of the available therapies for Graves' hyperthyroidism. Thionamides represent the treatment of choice in pregnant women, during lactation, in children and adolescents and in preparation for radioiodine therapy or thyroidectomy. Side effects are relatively frequent but are in general mild and transient. Two main regimens are available: titration method (use of the lowest dose maintaining euthyroidism; duration: 12 - 18 months) and block-and-replace method. Neither one has clear advantages in terms of outcome but the latter method is associated with more frequent side effects. Hyperthyroidism relapses in ∼ 50% of patients, to whom ablative therapy should be offered. © 2005 Ashley Publications Ltd.
2005
Graves' disease; Hyperthyroidism; Methimazole; Propylthiouracil; Thionamides;
Bartalena, Luigi; Tanda, MARIA LAURA PIERA; Piantanida, ELIANA ANGELA ROSA; Lai, Adriana; Martino, E.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1498047
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 14
social impact