Compounds of general formula (I): in which: R1 through R5 are as defined in the specification FG, which can be the same or different, are carboxy, -PO3H2 or -RP(O)OH groups, wherein R is hydrogen, or an optionally substituted group selected from C1-C20 alkyl, C3-C10 cycloalkyl, C4-C20 cycloalkylalkyl, aryl, arylalkyl, a group bearing an acidic moiety, and a group bearing an amino moiety, each of which may be further optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among <203>Pb, <67>Ga, <68>Ga, <72>As, <111>In, <113>In, <90>Y, <97>Ru, <62>Cu, <64>Cu, <52>Fe, <52m>Mn, <140>La, <175>Yb, <153>Sm, <166>Ho, <149>Pm, <177>Lu, <142>Pr, <159>Gd, <212>Bi, <47>Sc, <149>Pm, <67>Cu, <111>Ag, <199>Au, <161>Tb, <51>Cr, <167>Tm, <141>Ce, <168>Yb, <88>Y, <165>Dy, <166>Dy, <97>Ru, <103>Ru, <186>Re, <188>Re, <99m>Tc, <211>Bi, <212>Bi, <213>Bi, <214>Bi, <105>Rh, <109>Pd, <117m>Sn, <177>Sn and <199>Au, as well as the salts thereof with physiologically compatible bases or acids.
MULTIDENTATE AZA LIGANDS ABLE TO COMPLEX METAL IONS AND THEIR USE IN DIAGNOSTICS AND THERAPY
PALMISANO, GIOVANNI;
2006-01-01
Abstract
Compounds of general formula (I): in which: R1 through R5 are as defined in the specification FG, which can be the same or different, are carboxy, -PO3H2 or -RP(O)OH groups, wherein R is hydrogen, or an optionally substituted group selected from C1-C20 alkyl, C3-C10 cycloalkyl, C4-C20 cycloalkylalkyl, aryl, arylalkyl, a group bearing an acidic moiety, and a group bearing an amino moiety, each of which may be further optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among <203>Pb, <67>Ga, <68>Ga, <72>As, <111>In, <113>In, <90>Y, <97>Ru, <62>Cu, <64>Cu, <52>Fe, <52m>Mn, <140>La, <175>Yb, <153>Sm, <166>Ho, <149>Pm, <177>Lu, <142>Pr, <159>Gd, <212>Bi, <47>Sc, <149>Pm, <67>Cu, <111>Ag, <199>Au, <161>Tb, <51>Cr, <167>Tm, <141>Ce, <168>Yb, <88>Y, <165>Dy, <166>Dy, <97>Ru, <103>Ru, <186>Re, <188>Re, <99m>Tc, <211>Bi, <212>Bi, <213>Bi, <214>Bi, <105>Rh, <109>Pd, <117m>Sn, <177>Sn and <199>Au, as well as the salts thereof with physiologically compatible bases or acids.
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