The study reports data on respiratory function of lung and chest wall following the 180 days long European - Russian EuroMir ‘95 space mission. Two subjects were studied before the mission, on day 9 and 175 in flight and on days 1, 10, 12,27 and 120 after return. In-flight vital capacity (VC) and expiratory reserve volume (ERV) were similar to those in supine posture, namely - 5% and - 30% less than in sitting posture. On day 1 after return, VC was reduced by -30 % in both postures. This reflected a decrease in ERV (-0.5 L) and in IC (inspiratory capacity, - 1.7 L) that could be attributed to a marked weakening of the respiratory muscles. Regain of normal preflight values barely occurred 120 days after return. Post-flight pressure-volume curves of the lung, chest wall and total respiratory system are equal to preflight ones. The pressure-volume curve of the lung in supine posture is displaced to the right relative to sitting posture and shows a lower compliance. As far as the lung in-flight condition resembles that occurring in supine posture, this implies a lower compliance, a greater amount of blood in the pulmonary microvascular bed, a more homogeneous lung perfusion and therefore a greater microvascular filtration rate towards lung interstitium.
Interstitial fluid balance under zero-g, with special reference to pulmonary mechanics
NEGRINI, DANIELA;
1995-01-01
Abstract
The study reports data on respiratory function of lung and chest wall following the 180 days long European - Russian EuroMir ‘95 space mission. Two subjects were studied before the mission, on day 9 and 175 in flight and on days 1, 10, 12,27 and 120 after return. In-flight vital capacity (VC) and expiratory reserve volume (ERV) were similar to those in supine posture, namely - 5% and - 30% less than in sitting posture. On day 1 after return, VC was reduced by -30 % in both postures. This reflected a decrease in ERV (-0.5 L) and in IC (inspiratory capacity, - 1.7 L) that could be attributed to a marked weakening of the respiratory muscles. Regain of normal preflight values barely occurred 120 days after return. Post-flight pressure-volume curves of the lung, chest wall and total respiratory system are equal to preflight ones. The pressure-volume curve of the lung in supine posture is displaced to the right relative to sitting posture and shows a lower compliance. As far as the lung in-flight condition resembles that occurring in supine posture, this implies a lower compliance, a greater amount of blood in the pulmonary microvascular bed, a more homogeneous lung perfusion and therefore a greater microvascular filtration rate towards lung interstitium.
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