BACKGROUND:Sinonasal mucosal melanoma is a rare malignancy with poor prognosis. METHODS:Patients with sinonasal malignant melanoma who underwent surgery by different approaches were included in this study. Overall survival (OS) and event-free survival were calculated, and statistically significant variables by univariate analysis were entered in a multivariate Cox regression model. RESULTS:Pathological staging was pT3, pT4a, and pT4b in 30 cases (51.7%), 17 cases (29.3%), and 11 cases (19.0%). At 3 and 5 years, OS was 43.5% and 29% and event-free survival was 23.6% and 12.4%, respectively. At univariate analysis, OS was significantly influenced by male sex, advanced pT classification, positive margins, and surgical approach; event-free survival was affected by positive margins. At multivariate analysis, the risk of death was independently associated with male sex (hazard ratio [HR] = 2.27; p = .04) and positive margins (HR = 2.32; p = .03). CONCLUSION:Male sex and positive margins were negative prognostic factors. Endoscopic resection did not show an increased risk of death compared with more extensive surgical approaches.

Sinonasal mucosal melanoma: A 12-year experience of 58 cases

BATTAGLIA, PAOLO;CASTELNUOVO, PAOLO GIOCONDO MARIA;SESSA, FAUSTO;TURRI ZANONI, MARIO
2016-01-01

Abstract

BACKGROUND:Sinonasal mucosal melanoma is a rare malignancy with poor prognosis. METHODS:Patients with sinonasal malignant melanoma who underwent surgery by different approaches were included in this study. Overall survival (OS) and event-free survival were calculated, and statistically significant variables by univariate analysis were entered in a multivariate Cox regression model. RESULTS:Pathological staging was pT3, pT4a, and pT4b in 30 cases (51.7%), 17 cases (29.3%), and 11 cases (19.0%). At 3 and 5 years, OS was 43.5% and 29% and event-free survival was 23.6% and 12.4%, respectively. At univariate analysis, OS was significantly influenced by male sex, advanced pT classification, positive margins, and surgical approach; event-free survival was affected by positive margins. At multivariate analysis, the risk of death was independently associated with male sex (hazard ratio [HR] = 2.27; p = .04) and positive margins (HR = 2.32; p = .03). CONCLUSION:Male sex and positive margins were negative prognostic factors. Endoscopic resection did not show an increased risk of death compared with more extensive surgical approaches.
2016
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347
Endoscopic surgery; Mucosal melanoma; Prognosis; Sinonasal tract; Survival; Otorhinolaryngology2734 Pathology and Forensic Medicine
Lombardi, Davide; Bottazzoli, Marco; Turri Zanoni, Mario; Raffetti, Elena; Villaret, Andrea Bolzoni; Morassi, Maria Laura; Ungari, Marco; Vermi, William; Battaglia, Paolo; Castelnuovo, PAOLO GIOCONDO MARIA; Facco, Carla; Sessa, Fausto; Donato, Francesco; Nicolai, Piero; TURRI ZANONI, Mario
File in questo prodotto:
File Dimensione Formato  
Lombardi_et_al-2016-Head_&_Neck.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Licenza: DRM non definito
Dimensione 949.98 kB
Formato Adobe PDF
949.98 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2031335
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 62
  • ???jsp.display-item.citation.isi??? 52
social impact