In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.

Keratin-hydrotalcites hybrid films for drug delivery applications

Gariboldi M;
2018-01-01

Abstract

In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.
2018
Composites; Cytocompatibility; Drug release; Hydrotalcytes; Keratin; Physics and Astronomy (all); Polymers and Plastics; Organic Chemistry
Posati, T; Giuri, D; Nocchetti, M; Sagnella, A; Gariboldi, M; Ferroni, C; Sotgiu, G; Varchi, G; Zamboni, R; Aluigi, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2074611
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