During recent years it has become evident that the extracellular matrix is not merely a "passive" supporting framework for the tissues, but a structure which can influence dynamic events in the organs. As one example, changes in the matrix structure, via an integrin-mediated mechanism, appears to "actively" contribute to the rapid swelling (edema formation) in inflammation. Also in other tissues, members of the teams have demonstrated that alterations in the extracellular matrix will induce measurable changes in physiological parameters. The research carried out by the members of the network explored the dynamic function of the extracellular matrix through an integrated research effort on four distinct projects: 1. Structure-function of the extracellular matrix 2. Interstitial body cavities (pleura, peritoneum, synovium) 3. Interstitial-Microvascular exchange in special organs 4. Lymph formation
Interstitial mechanics and Transport
NEGRINI, DANIELA
1998-01-01
Abstract
During recent years it has become evident that the extracellular matrix is not merely a "passive" supporting framework for the tissues, but a structure which can influence dynamic events in the organs. As one example, changes in the matrix structure, via an integrin-mediated mechanism, appears to "actively" contribute to the rapid swelling (edema formation) in inflammation. Also in other tissues, members of the teams have demonstrated that alterations in the extracellular matrix will induce measurable changes in physiological parameters. The research carried out by the members of the network explored the dynamic function of the extracellular matrix through an integrated research effort on four distinct projects: 1. Structure-function of the extracellular matrix 2. Interstitial body cavities (pleura, peritoneum, synovium) 3. Interstitial-Microvascular exchange in special organs 4. Lymph formation
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
