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Prodotti recenti

From Wound Dressing to Tissue Regeneration: Bilayer Medicated Patches for Personalized Treatments of Chronic Wounds

Chronic wounds pose a significant healthcare challenge, impairing the quality of life for millions of affected individuals. This phenomenon escalates due to the aging of the population and rising comorbidities. Traditional wound care methods often prove inadequate in dealing with the complexities of chronic wounds; therefore, biomaterials have emerged as promising solutions. In response to this need, this work focuses on the development of a bilayered hybrid patch for the treatment of chronic...

The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners

The identification of molecules that make cancer cells detectable by the immune system represents a major challenge in tumor immunology. Alarmins, endogenous, stress-induced molecules, serve as early warning signals triggering immune responses. The human RNASET2 protein has demonstrated both oncosuppressive and immunoregulatory functions across various cancer types, yet its role as an oncosuppressor or alarmin-like molecule in prostate cancer (PCa) is unexplored. Here, we investigated the eff...

Epigenetics: A link between toxicants and diseases

Epigenetics is a complex network of molecular mechanisms, including DNA modifications, histone modifications, and non-coding RNA transcripts that influence gene transcription in heritable ways across cells. Over the last decades, epigenetic mechanisms have gained significant attention in the field of toxicology. Various research groups are investigating the epigenetic impact of toxicants due to their role in mediating the effects of environmental factors on cellular function, in complex disea...

Post-pandemic upsurge in Group A Streptococcus infections at an Italian tertiary university hospital

Streptococcus pyogenes (Group A Streptococcus; GAS) is a pathogen of global significance. In the pre-antibiotic era, GAS was a major cause of childhood morbidity and mortality, but its spread rapidly declined until the mid-2010s. The continuing increase in GAS infections, associated with the expansion of the M1(UK) lineage, was observed first in the United Kingdom (UK) and, later, globally. Here, we endeavor to assess the various determinants underlying the post-pandemic GAS upsurge, with a f...

Varese sacra e universitaria: dinamiche storico-trasformative tra arte, architettura, turismo e urbanistica

The essay intends to analyze aspects, dynamics and perspectives inherent to the dialectics of the present vocation of Varese as a university city, both with respect to the previous transformative phases of the city (religious center, following the foundation of the Sacro Monte, a place of noble holiday resort in the 18th–early 20th, provincial capital since 1927), and to future prospects, in particular connected to the redevelopment of the Rectorate area as an urban cultural centre.

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