IoT-driven blockchain to manage the healthcare supply chain and protect medical records

Healthcare supply chain domain and medical records’ management face numerous challenges that come with new demands, such as customer dissatisfaction, rising healthcare costs, tracking and traceability of drugs, and security and privacy related to the sensitive information managed in such a domain. Executing processes related to healthcare domain in a trusted, secure, efficient, accessible and traceable manner is challenging due to the fragmented nature of the healthcare supply chain, which is...

Efficacy of front-line ibrutinib versus fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia: A retrospective multicenter “Real-World” study

High rate of durable responses with undetectable minimal residual disease with frontline venetoclax and rituximab in young and fit patients with chronic lymphocytic leukemia and an adverse biologic profile: results of the gimema phase II LLC1518 - 'Veritas' study

The GIMEMA phase II LLC1518 VERITAS trial investigated the efficacy and safety of frontline, fixed-duration venetoclax and rituximab (VenR) combination in young (≤65 years) and fit patients with chronic lymphocytic leukemia (CLL) and unmutated IGHV and/or TP53 disruption. Treatment consisted of the Ven ramp-up, six-monthly courses of the VenR combination, followed by six monthly courses of Ven single agent. A centralized assessment of measurable minimal residual disease (MRD) was performed on...

Ibrutinib as first line therapy in chronic lymphocytic leukemia patients over 80 years old: a retrospective real‐life multicenter Italian cohort

Although chronic lymphocytic leukemia (CLL) predominantly affects the elderly, limited data exists about the outcomes of over 80-year-old patients, usually underrepresented in clinical trials. We conducted a multicenter study enrolling 79 consecutive CLL patients >= 80 years at the time of frontline therapy, all treated with ibrutinib. Nearly 48% of cases exhibited unmutated IGHV genes, 32% 17p deletion, and 39.2% TP53 mutations; 63.3% displayed a cumulative illness rating scale (CIRS) >...