Prescribing cascades among hospitalized older adults: a retrospective cohort study from the REPOSI registry

A prescribing cascade occurs when an adverse drug reaction (ADR) generated from an index drug (Drug A) is mistaken for a new medical condition that is in turn managed with a new drug prescription (Drug B). Prescribing cascades represent a factor influencing inappropriate prescribing and unnecessary polypharmacy, especially among older adults. Using the REPOSI registry, we conduct a retrospective observational study to examine the prevalence of potential prescribing cascades, as identified in ...

Orthostatic Hypotension in Hypertensive Patients Hospitalized in Italian Internal Medicine Departments: FADOI-HYP-OP Study

Introduction Orthostatic hypotension (OH) is defined as a decline in systolic blood pressure of at least 20 mmHg or a reduction in diastolic blood pressure of at least 10 mmHg, within the first 3 min of standing.Aim To evaluate the prevalence of OH and to identify the characteristics of patients with OH in hypertensive patients hospitalized in medical inpatient departments.Methods A multicenter, observational, prospective study (FADOI-HYP-OP) included 1000 hypertensive inpatients from 29 Depa...

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PM2.5 and PM10 exposure assessment: a comparative analysis between personal monitoring and environmental data

The evaluation of personal exposure to PM is a critical component of risk assessment: one of the main challenges is represented by the difficulty in simultaneously obtaining extensive and accurate personal exposure data for large populations. This study provides an empirical comparison between personal PM2.5 and PM10 exposure measurements and routinely available ambient data from fixed monitoring stations and air quality models in a hybrid working scenario. Time-activity information was also ...