Truncated minimal-norm Gauss-Newton method applied to the inversion of FDEM data

Electromagnetic induction techniques are among the most popular methods for non-invasive investigation of the soil. The collection of data is allowed by frequency domain electromagnetic devices. Starting from these data, the reconstruction of some soil properties is a challenging task, as the inverse problem is ill-posed, meaning that the problem is underdetermined, ill-conditioned, that is, the solution is sensitive to the presence of noise in the data, and nonlinear. Iterative procedures ...

Computational simulation of diaphragmatic lymphatics' intrinsic activity

Spontaneous contractile activity has been observed in FITC-dextran-filled lymphatic vessels located along the peripheral margin of the pleural diaphragm in anesthetized adult Wistar rats. Based on their contractile behavior, individual lymphatic segments were grouped into four functional categories: active spontaneously contracting, stretch-responsive, passive, and non-contractile. Unlike central collectors, the most peripheral loops of the diaphragmatic lymphatic network, located in the musc...

Lymphatics and pleural disease

34 | Dissecting the spectrum of rare BRAF mutations in melanoma: a nation-wide study by the Italian Melanoma Intergroup

Introduction: Non-V600E/K BRAF mutations have been reported in melanoma, but data on their clinical relevance are conflicting. This study investigated the distribution, prognostic role and functional impact of rare BRAF mutations in melanoma. Methods: We retrospectively assessed frequency, response to therapy and outcome of rare BRAF mutations compared to V600E/K in cases from 19 Italian Melanoma group (IMI) centers. Results: 258/14081 samples (1.8%) harbored rare BRAF mutations, 40% en...