CARATTERIZZAZIONE FUNZIONALE E FENOTIPICA DELLE CELLULE NATURAL KILLER CIRCOLANTI E TUMORALI IN PAZIENTI CON CANCRO DELLA PROSTATA

Le cellule Natural Killer (NK) sono cellule linfoidi innate (ILC) coinvolte nel riconoscimento/eliminazione del tumore e sono state trovate alterate in diversi tumori, incluso il cancro alla prostata (PCa). Inoltre, è stato scoperto che le cellule NK acquisiscono fenotipo/funzioni pro-angiogenici nel cancro solido. Ho caratterizzato le cellule NK circolanti (TANK) e infiltranti il tumore (TINK) in pazienti con cancro alla prostata, iperplasia prostatica benigna (BPH), rispetto a quelle di ind...

Utilizzo di fonti proteiche alternative e probiotici nella dieta di specie ittiche allevate: effetti sul microbioma e salute intestinale.

In a scenario of growing food demand due to the rapid increase in the world’s population, which is estimated to reach 9.7 billion people by the end of 2050, agriculture is facing an enormous challenge. In this context, aquaculture represents the fastest growing food provider industry, but also one which only has a minor impact in terms of environmental footprint. However, a limitation to expanding the sector lies in the need for advancing technology, management, regulations, and, to the large...

A novel and validated agile Ontology Engineering methodology for the development of ontology-based applications

The goal of this Thesis is to investigate the status of Ontology Engineering, underlining the main key issues still characterizing this discipline. Among these issues, the problem of reconciling macro-level methodologies with authoring techniques is pivotal in supporting novel ontology engineers. The latest approach characterizing ontology engineering methodologies leverages the agile paradigm to support collaborative ontology development and deliver efficient ontologies. However, so far, the...

Geometric, Stochastic and Spectral properties of Graphs: theory and numerical applications