Saccadic eye movements are studied in patients suffering from multiple sclerosis during a worsening of the disease, before and after high-dose 6-methylprednisolone infusions. The quantitative evaluation was based on the amplitude-duration and amplitude-peak velocity relationships, the precision (i.e., the ratio of actual to desired saccade amplitude) and the latency of saccades. At basal recordings, 15 of the 17 patients showed at least one abnormality. The amplitude-duration relationship improved in one patient and worsened in two patients; the amplitude-peak velocity relationship improved in one and worsened in another patient; and the precision and the latency improved in one and seven patients respectively. In the whole group of patients, the only parameter which showed a significant modification (improvement) was the latency. Finally, the neurophysiological modifications did not match clinical changes. © 1994 Elsevier B.V.

Saccades and 6-Methylprednisolone Treatment in Multiple Sclerosis

Versino, Maurizio;
1994-01-01

Abstract

Saccadic eye movements are studied in patients suffering from multiple sclerosis during a worsening of the disease, before and after high-dose 6-methylprednisolone infusions. The quantitative evaluation was based on the amplitude-duration and amplitude-peak velocity relationships, the precision (i.e., the ratio of actual to desired saccade amplitude) and the latency of saccades. At basal recordings, 15 of the 17 patients showed at least one abnormality. The amplitude-duration relationship improved in one patient and worsened in two patients; the amplitude-peak velocity relationship improved in one and worsened in another patient; and the precision and the latency improved in one and seven patients respectively. In the whole group of patients, the only parameter which showed a significant modification (improvement) was the latency. Finally, the neurophysiological modifications did not match clinical changes. © 1994 Elsevier B.V.
1994
Elsevier
9780444818089
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2153331
 Attenzione

L'Ateneo sottopone a validazione solo i file PDF allegati

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact