The digestive system represents the most common localization for neuroendocrine neoplasms (NEN) in the human body. Despite a common classification and some unifying characteristics, for example the tissue and serum markers used for their identification and characterization and their features at imaging, NEN of the digestive system display a high level of morphological, molecular, clinical, and biological heterogeneity. This is partially related to distinct causative factors and pathogenetic mechanisms, which are peculiar to the specific localizations in the digestive system. This chapter presents a comprehensive overview of NEN of the digestive system with focus on their epidemiology, histopathology, molecular biology, imaging characteristics, and therapeutic options. Subchapters deal with the problematic of differential diagnosis and treatment of hepatic metastases of NEN, which frequently represent a clinical challenge, and with NEN occurring in the context of genetic syndromes.[Aspects of disease that affe

Neuroendocrine Neoplasms of the Digestive System

La Rosa S.;
2024-01-01

Abstract

The digestive system represents the most common localization for neuroendocrine neoplasms (NEN) in the human body. Despite a common classification and some unifying characteristics, for example the tissue and serum markers used for their identification and characterization and their features at imaging, NEN of the digestive system display a high level of morphological, molecular, clinical, and biological heterogeneity. This is partially related to distinct causative factors and pathogenetic mechanisms, which are peculiar to the specific localizations in the digestive system. This chapter presents a comprehensive overview of NEN of the digestive system with focus on their epidemiology, histopathology, molecular biology, imaging characteristics, and therapeutic options. Subchapters deal with the problematic of differential diagnosis and treatment of hepatic metastases of NEN, which frequently represent a clinical challenge, and with NEN occurring in the context of genetic syndromes.[Aspects of disease that affe
2024
9781119756392
9781119756422
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2179975
 Attenzione

L'Ateneo sottopone a validazione solo i file PDF allegati

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact