Viral, bacterial, prion, and fungal infections have been transmitted via tissue allografts such as bone, tendon, skin, cornea, dura mater, pericardium, blood vessels, and heart valves. Over the past several years, improvements in tissue donor suitability requirements and donor blood testing have greatly reduced this risk. For example, improved tissue banking standards and practices currently in place would have prevented previously reported cases of disease transmission that resulted from the use of hemodiluted blood samples for infectious disease testing (there have been human immunodeficiency virus [HIV] transmissions by organs because of hemodilution), accepting donors with behavioral risks for HIV infection, and using early generation, less sensitive tests for HIV and hepatitis C virus (HCV) antibodies. In this chapter, donor blood testing, its rationale, the challenges associated with testing in general, bacterial and fungal testing of tissues and new technologies for viral and bacterial testing are discussed.

THE ROLE OF TESTING IN DETERMINING SUITABILITY OF DONORS AND TISSUES

GROSSI, PAOLO ANTONIO;
2009-01-01

Abstract

Viral, bacterial, prion, and fungal infections have been transmitted via tissue allografts such as bone, tendon, skin, cornea, dura mater, pericardium, blood vessels, and heart valves. Over the past several years, improvements in tissue donor suitability requirements and donor blood testing have greatly reduced this risk. For example, improved tissue banking standards and practices currently in place would have prevented previously reported cases of disease transmission that resulted from the use of hemodiluted blood samples for infectious disease testing (there have been human immunodeficiency virus [HIV] transmissions by organs because of hemodilution), accepting donors with behavioral risks for HIV infection, and using early generation, less sensitive tests for HIV and hepatitis C virus (HCV) antibodies. In this chapter, donor blood testing, its rationale, the challenges associated with testing in general, bacterial and fungal testing of tissues and new technologies for viral and bacterial testing are discussed.
2009
9781405163224
File in questo prodotto:
File Dimensione Formato  
Grossi Tissue and Cell Donation c06.pdf

non disponibili

Tipologia: Altro materiale allegato
Licenza: DRM non definito
Dimensione 1.05 MB
Formato Adobe PDF
1.05 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/5899
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? ND
social impact