Most ion-coupled cotransporters display, in the absence of organic substrate, transient currents resembling the gating currents of voltage-dependent ion channels. Detailed comparison of these currents in different ionic and temperature conditions with the corresponding steady-state currents when translocation of the substrate occurs reveals new insights into the mechanisms of the process.
Electrophysiological insights into the mechanism of ion-coupled cotransporters
PERES, ANTONIO;GIOVANNARDI, STEFANO;BOSSI, ELENA;FESCE, RICCARDO GIUSEPPE
2004-01-01
Abstract
Most ion-coupled cotransporters display, in the absence of organic substrate, transient currents resembling the gating currents of voltage-dependent ion channels. Detailed comparison of these currents in different ionic and temperature conditions with the corresponding steady-state currents when translocation of the substrate occurs reveals new insights into the mechanisms of the process.
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