In the tentacle of Sepia officinalis, smooth-like, helical and cross-striated fibres deriving from different populations of myoblasts are present. Myoblasts appear at different times during the development and express two muscle-specific transcription factors: Myf5-like and MyoD-like factors. Myoblasts expressing Myf5 give rise to slow fibres, whereas fast fibres derive from MyoD+ myoblasts. We found that a Hedgehog (Hh)-like signal was present in the central nerve cord of the tentacle from the early stages of development and in a specific population of myoblasts which are the precursors of slow muscle fibres. The model showed interesting similarities with vertebrates, in which Sonic hedgehog is a protein secreted by axial structures (the notochord and neurotube) and is involved in slow muscle differentiation and in survival of muscle precursors.

A hedgehog-like signal is involved in slow muscle differentation in Sepia officinalis (Mollusca)

GRIMALDI, ANNALISA;TETTAMANTI, GIANLUCA;GUIDALI, MARIA LUISA;BRIVIO, MAURIZIO FRANCESCO;VALVASSORI, ROBERTO;DE EGUILEOR, MAGDA ANNA
2007-01-01

Abstract

In the tentacle of Sepia officinalis, smooth-like, helical and cross-striated fibres deriving from different populations of myoblasts are present. Myoblasts appear at different times during the development and express two muscle-specific transcription factors: Myf5-like and MyoD-like factors. Myoblasts expressing Myf5 give rise to slow fibres, whereas fast fibres derive from MyoD+ myoblasts. We found that a Hedgehog (Hh)-like signal was present in the central nerve cord of the tentacle from the early stages of development and in a specific population of myoblasts which are the precursors of slow muscle fibres. The model showed interesting similarities with vertebrates, in which Sonic hedgehog is a protein secreted by axial structures (the notochord and neurotube) and is involved in slow muscle differentiation and in survival of muscle precursors.
2007
http://www.isj.unimo.it/articoli/ISJ125.pdf
Development; Helical and cross-striated fibres; Hh-like protein; Mollusc; Muscle differentiation;
Grimaldi, Annalisa; Tettamanti, Gianluca; Guidali, MARIA LUISA; Brivio, MAURIZIO FRANCESCO; Valvassori, Roberto; DE EGUILEOR, MAGDA ANNA
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1668358
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