Ambulatory blood pressure, nocturnal blood pressure reduction and plasma catecholamines

Objective and design. Controversial data have been reported on plasma catecholamines in hypertensives. Aims of this study were to find whether 24-hour ambulatory blood pressure was correlated with circulating catecholamines and to investigate whether nocturnal blood pressure reduction was associated with baseline plasma catecholamines. Samples for catecholamine determination were obtained in 34 consecutive male subjects after a 30-minute rest and before ambulatory blood pressure monitoring. Results. Hypertensive patients (n=22; 24-hour blood pressure: 145+/-14/94+/-6 mm Hg) showed similar norepinephrine and epinephrine levels when compared with normotensives (n=12; 24-hour blood pressure: 124+/-6/81+/-6 mm Hg), and higher dopamine values (hypertensives: 64.6+/-58; normotensives: 26.2+/-31 pg/ml; p<0.05). A positive correlation was observed between dopamine and diastolic nocturnal blood pressure (p<0.05) while a negative correlation was found between dopamine and nocturnal diastolic blood pressure reduction (p<0.025). No significant relationship was observed between both norepinephrine and epinephrine, and 24-hour blood pressures. Conclusions. Since previous reports have documented malfunctioning of dopaminergic system in hypertension, the higher levels of circulating plasma dopamine found in hypertensive patients in the present study may account for a peripheral compensatory increase. The correlation between dopamine and nocturnal blood pressure fall seems to indicate that the impairment of dopaminergic system may influence the 24-hour blood pressure profile, affecting the nocturnal blood pressure reduction.