The RNASET2 gene, mapped in 6q27, was previously found to exert control of tumorigenesis in an ovarian cancer system. We present here results indicating a similar control in a melanoma cancer model. Thus, this gene is most likely involved in a common general pathway of tumorigenesis. Moreover, its antitumorigenic activity is manifested in vivo but not in vitro, suggesting that this gene belongs to the growing category of tumor antagonizing/malignancy suppressor genes. A possible role of RNASET2 in the activation of a senescence program, whose responsible locus was mapped in the same chromosomal 6q27 region, seems to be inconsistent with our data.

RNASET2 as a tumor antagonizing gene in a melanoma cancer model

NOONAN, DOUGLAS;ACQUATI, FRANCESCO;TARAMELLI, ROBERTO
2008

Abstract

The RNASET2 gene, mapped in 6q27, was previously found to exert control of tumorigenesis in an ovarian cancer system. We present here results indicating a similar control in a melanoma cancer model. Thus, this gene is most likely involved in a common general pathway of tumorigenesis. Moreover, its antitumorigenic activity is manifested in vivo but not in vitro, suggesting that this gene belongs to the growing category of tumor antagonizing/malignancy suppressor genes. A possible role of RNASET2 in the activation of a senescence program, whose responsible locus was mapped in the same chromosomal 6q27 region, seems to be inconsistent with our data.
http://www.ingentaconnect.com/contentone/cog/or/2008/00000017/00000002/art00003
Monti, Laura; Rudolfo, M; LO RUSSO, G; Noonan, Douglas; Acquati, Francesco; Taramelli, Roberto
File in questo prodotto:
File Dimensione Formato  
Oncol Res 2008.pdf

accesso aperto

Descrizione: PDF editoriale
Tipologia: Altro materiale allegato
Licenza: Creative commons
Dimensione 3.86 MB
Formato Adobe PDF
3.86 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1707113
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 27
social impact