A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedländer cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30 min), the reaction was also feasible under conventional heating (with fair to good yields in about 5 h).
|Data di pubblicazione:||2010|
|Titolo:||FAST, SOLVENT-FREE, MICROWAVE-PROMOTED FRIEDLÄNDER ANNULATION WITH A REUSABLE SOLID CATALYST|
|Digital Object Identifier (DOI):||10.1080/00397910902957407|
|Codice identificativo ISI:||WOS:000272680800014|
|Codice identificativo Scopus:||2-s2.0-72049094256|
|Parole Chiave:||Friedländer synthesis; microwaves; quinoline; solid catalyst; solvent-free|
|Appare nelle tipologie:||Articolo su Rivista|