A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedländer cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30 min), the reaction was also feasible under conventional heating (with fair to good yields in about 5 h).
FAST, SOLVENT-FREE, MICROWAVE-PROMOTED FRIEDLÄNDER ANNULATION WITH A REUSABLE SOLID CATALYST
PALMISANO, GIOVANNI;
2010-01-01
Abstract
A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedländer cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30 min), the reaction was also feasible under conventional heating (with fair to good yields in about 5 h).
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