The pharmacological profile of the lignan 7-hydroxymatairesinol (HMR/lignan, HMR) includes chemopreventive effects, antioxidant properties, and mild proestrogenic activity. The present study was devised to investigate the effects of HMR on THP-1 cells, an established model of human monocytes, and on human polymorphonuclear leukocytes (PMNs). In THP-1 cells, HMR concentration-dependently reduced LPS-stimulated tumor necrosis factor (TNF)-alpha secretion in the supernatant. HMR at low, sub-muM concentrations also reduced TNF-alpha mRNA, which was however enhanced by supra-muM concentrations of HMR. In human PMNs, HMR concentration-dependently reduced ROS production induced by either N-formyl-Met-Leu-Phe, phorbol myristate acetate or angiotensin II, as well as interleukin-8 production induced by either N-formyl-Met-Leu-Phe or angiotensin II. Results indicate that HMR is an effective inhibitor of both monocytic THP-1 cells and of human PMNs and warrant further studies to assess their relevance for the prevention and treatment of several conditions characterized by chronic systemic inflammation.
|Data di pubblicazione:||2010|
|Titolo:||Immunomodulatory activity of the lignan 7-hydroxymatairesinol potassium acetate (HMR/LignanTM) extracted from the heartwood of norway spruce (Picea abies)|
|Codice identificativo ISI:||WOS:000275925700012|
|Codice identificativo Scopus:||2-s2.0-76849111837|
|Codice identificativo Pubmed:||20005303|
|Appare nelle tipologie:||Articolo su Rivista|