Meridianins, marine alkaloids known as kinase inhibitors with an indole skeleton, and meridianin analogues were produced regioselectively and in moderate to good yields by thermal annulation of nitrosoarenes with 2-amino-4-ethynylpyrimidine and 2-chloro-4-ethynylpyrimidine, respectively, through a novel and atom-economical indolization process.

One-pot Synthesis of Meridianins and Meridianin Analogues via Indolization of Nitrosoarenes

PALMISANO, GIOVANNI;TOLLARI, STEFANO;PENONI, ANDREA
2010-01-01

Abstract

Meridianins, marine alkaloids known as kinase inhibitors with an indole skeleton, and meridianin analogues were produced regioselectively and in moderate to good yields by thermal annulation of nitrosoarenes with 2-amino-4-ethynylpyrimidine and 2-chloro-4-ethynylpyrimidine, respectively, through a novel and atom-economical indolization process.
Meridianins; Indoles; Alkynes; Nitrosoarenes; Kinase inhibitors
Tibiletti, F.; Simonetti, M.; Nicholas, K. M.; Palmisano, Giovanni; Parravicini, M.; Imbesi, F.; Tollari, Stefano; Penoni, Andrea
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1715770
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