Abstract Purpose:To evaluate subfoveal choroidal thickness before and after laser photocoagulation in diabetic retinopathy (DR) visualized by Spectral Domain OCT (SDOCT). Methods:A total of 15 patients affected by DR were involved in this prospective interventional study. Inclusion criteria comprehend DR complicated by significant macular edema or retinal ischemia. Exclusion criteria include media opacities, other vascular or inflammatory retinal pathologies. Seven patients received scatter laser photocoagulation for proliferative DR and eight patients focal or laser grid photocoagulation for diabetic macular edema. By means of a SDOCT (OTI-OPKO, Toronto, Canada) experienced operators measured choroidal thickness in subfoveal area and 3mm away from the fovea in nasal and temporal region, after imaging enhancement procedures. Clinical measurements were performed at baseline, at day 7 and day 14 after laser treatment. Statistical analysis was performed to compare the results. Results:Choroidal and retinal thickness OCT measurements were performed to all subjects on scheduled visits. Mean choroidal thickness at baseline was respectively 250,7 ± 60,6µm in subfoveal region, 166,4 ± 63µm nasal to fovea and 241,4 ± 66µm temporal to fovea; at day 7 was 280,8 ± 76µm (p=0.01), 180,8 ± 63µm (p>0.05) and 239,2 ± 67µm (p>0.05); at day 15, mean choroidal thickness was 246,3 ± 62µm (p=0.03), 171,8 ± 65µm (p>0.05) and 240 ± 68,8µm (p>0.05). Retinal macular thickness measured underwent to an overall variation during follow up from a baseline value of 286,4±60,01µm to 323±75,9µm at day 7 (p=0.03) and to 310,9±62,01µm at day 15 (p>0.05). Conclusions:Our study showed at day 7 a statistically significant increase of choroidal thickness only in subfoveal region, subsequently decreased at day 14. This observation was associated to a significant increase of retinal thickness at day 7. These observations underline and confirm the involvement of choroidal tissue on different traumatic and inflammatory vitreoretinal events, as well as the role of new SDOCT to better evaluate and measure choroidal structure.
Submacular Choroidal Thickness Evaluation After Laser Photocoagulation For Diabetic Retinopathy
DONATI, SIMONEWriting – Original Draft Preparation
;CHELAZZI, PAOLO;AZZOLINI, CLAUDIO
2011-01-01
Abstract
Abstract Purpose:To evaluate subfoveal choroidal thickness before and after laser photocoagulation in diabetic retinopathy (DR) visualized by Spectral Domain OCT (SDOCT). Methods:A total of 15 patients affected by DR were involved in this prospective interventional study. Inclusion criteria comprehend DR complicated by significant macular edema or retinal ischemia. Exclusion criteria include media opacities, other vascular or inflammatory retinal pathologies. Seven patients received scatter laser photocoagulation for proliferative DR and eight patients focal or laser grid photocoagulation for diabetic macular edema. By means of a SDOCT (OTI-OPKO, Toronto, Canada) experienced operators measured choroidal thickness in subfoveal area and 3mm away from the fovea in nasal and temporal region, after imaging enhancement procedures. Clinical measurements were performed at baseline, at day 7 and day 14 after laser treatment. Statistical analysis was performed to compare the results. Results:Choroidal and retinal thickness OCT measurements were performed to all subjects on scheduled visits. Mean choroidal thickness at baseline was respectively 250,7 ± 60,6µm in subfoveal region, 166,4 ± 63µm nasal to fovea and 241,4 ± 66µm temporal to fovea; at day 7 was 280,8 ± 76µm (p=0.01), 180,8 ± 63µm (p>0.05) and 239,2 ± 67µm (p>0.05); at day 15, mean choroidal thickness was 246,3 ± 62µm (p=0.03), 171,8 ± 65µm (p>0.05) and 240 ± 68,8µm (p>0.05). Retinal macular thickness measured underwent to an overall variation during follow up from a baseline value of 286,4±60,01µm to 323±75,9µm at day 7 (p=0.03) and to 310,9±62,01µm at day 15 (p>0.05). Conclusions:Our study showed at day 7 a statistically significant increase of choroidal thickness only in subfoveal region, subsequently decreased at day 14. This observation was associated to a significant increase of retinal thickness at day 7. These observations underline and confirm the involvement of choroidal tissue on different traumatic and inflammatory vitreoretinal events, as well as the role of new SDOCT to better evaluate and measure choroidal structure.
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