1. The degree of tubular potassium depletion and the decrease of potassium conductance due to hyperpolarizing pulses in striated muscular fibres have been examined with the three micro-electrode voltage-clamp technique. 2. The conductance of the fibre membrane has been measured in different extracellular K+ concentrations from 1 to 10 mM. 3. Comparison of the two sets of measurements shows that changes in tubular K+ concentration are not sufficient to account for the conductance decrease associated with hyperpolarization. 4. The presence of a voltage-dependent gate in series with the inwardly rectifying channel for K+ ions, suggested by Almers (1972a, b), is thus confirmed.
|Data di pubblicazione:||1979|
|Titolo:||A voltage-dependent gate in series with the inwardly rectifying potassium channel in frog striated muscle.|
|Rivista:||THE JOURNAL OF PHYSIOLOGY|
|Codice identificativo Scopus:||2-s2.0-0018672283|
|Codice identificativo Pubmed:||315463|
|Appare nelle tipologie:||Articolo su Rivista|