Sympathoadrenergic pathways are crucial to the communication between the nervous system and the immune system. The present review addresses emerging issues in the adrenergic modulation of immune cells, including: the specific pattern of adrenoceptor expression on immune cells and their role and changes upon cell differentiation and activation; the production and utilization of noradrenaline and adrenaline by immune cells themselves; the dysregulation of adrenergic immune mechanisms in disease and their potential as novel therapeutic targets. A wide array of sympathoadrenergic therapeutics is currently used for non-immune indications, and could represent an attractive source of non-conventional immunomodulating agents.
|Data di pubblicazione:||2013|
|Titolo:||Adrenergic modulation of immune cells: an update|
|Digital Object Identifier (DOI):||10.1007/s00726-011-1186-6|
|Codice identificativo ISI:||WOS:000320372500005|
|Codice identificativo Scopus:||2-s2.0-84879248181|
|Codice identificativo Pubmed:||22160285|
|Appare nelle tipologie:||Articolo su Rivista|