Fracture non-unions often complicate orthopaedic trauma. BMPs (bone morphogenetic proteins) are currently considered the most appealing osteoinductive agents. Applications of BMP-7 since January 2004 were prospectively recorded in a multicentre registry of aseptic femoral non-unions. The study included 30 patients who had undergone a median of 1 revision operation before BMP-7 application and who were followed up for a median 24 months. In 23/30 cases the application of BMP-7 was combined with revision of the fixation, and in 12 it was combined also with autograft. Non-union healing was verified in 26/30 cases in a median period of 6 months. No adverse events were associated with BMP-7 application. Our case series supports the safety and efficacy of BMP-7 in femoral non-unions. Multicentre networks and systematic, long-term follow-up of patients may improve understanding of this promising osteoinductive bone substitute.
|Data di pubblicazione:||2009|
|Titolo:||Application of bone morphogenetic proteins to femoral non-unions: a 4-year multicentre experience.|
|Digital Object Identifier (DOI):||10.1016/S0020-1383(09)70013-0|
|Codice identificativo Scopus:||2-s2.0-77956013698|
|Codice identificativo Pubmed:||20082793|
|Parole Chiave:||Adult, Aged, Bone Morphogenetic Protein 7; administration /&/ dosage/therapeutic use, Drug Carriers, Female, Femoral Fractures; radiography/therapy, Follow-Up Studies, Fracture Fixation; methods, Fracture Healing; drug effects, Fractures; Ununited; radiography/therapy, Humans, Male, Middle Aged, Registries, Reoperation, Transplantation; Autologous, Treatment Outcome|
|Appare nelle tipologie:||Articolo su Rivista|