Fracture non-unions often complicate orthopaedic trauma. BMPs (bone morphogenetic proteins) are currently considered the most appealing osteoinductive agents. Applications of BMP-7 since January 2004 were prospectively recorded in a multicentre registry of aseptic femoral non-unions. The study included 30 patients who had undergone a median of 1 revision operation before BMP-7 application and who were followed up for a median 24 months. In 23/30 cases the application of BMP-7 was combined with revision of the fixation, and in 12 it was combined also with autograft. Non-union healing was verified in 26/30 cases in a median period of 6 months. No adverse events were associated with BMP-7 application. Our case series supports the safety and efficacy of BMP-7 in femoral non-unions. Multicentre networks and systematic, long-term follow-up of patients may improve understanding of this promising osteoinductive bone substitute.

Application of bone morphogenetic proteins to femoral non-unions: a 4-year multicentre experience.

CHERUBINO, PAOLO;
2009-01-01

Abstract

Fracture non-unions often complicate orthopaedic trauma. BMPs (bone morphogenetic proteins) are currently considered the most appealing osteoinductive agents. Applications of BMP-7 since January 2004 were prospectively recorded in a multicentre registry of aseptic femoral non-unions. The study included 30 patients who had undergone a median of 1 revision operation before BMP-7 application and who were followed up for a median 24 months. In 23/30 cases the application of BMP-7 was combined with revision of the fixation, and in 12 it was combined also with autograft. Non-union healing was verified in 26/30 cases in a median period of 6 months. No adverse events were associated with BMP-7 application. Our case series supports the safety and efficacy of BMP-7 in femoral non-unions. Multicentre networks and systematic, long-term follow-up of patients may improve understanding of this promising osteoinductive bone substitute.
http://dx.doi.org/10.1016/S0020-1383(09)70013-0
Adult, Aged, Bone Morphogenetic Protein 7; administration /&/ dosage/therapeutic use, Drug Carriers, Female, Femoral Fractures; radiography/therapy, Follow-Up Studies, Fracture Fixation; methods, Fracture Healing; drug effects, Fractures; Ununited; radiography/therapy, Humans, Male, Middle Aged, Registries, Reoperation, Transplantation; Autologous, Treatment Outcome
N. K., Kanakaris; N., Lasanianos; G. M., Calori; R., Verdonk; T. J., Blokhuis; Cherubino, Paolo; P. D., Biase; P. V., Giannoudis
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1761704
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 71
  • ???jsp.display-item.citation.isi??? ND
social impact