The effects induced in biological samples by free radicals generated during short periods (⩽ 5 min) of ultrasound irradiation have been investigated by following the decay kinetics of the electron paramagnetic resonance signal of the piperidine nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) in rat heart homogenates. Different kinetic models have been evaluated in order to identify the reactions involved in nitroxide decay. The results obtained indicate that sonication, however short its duration, significantly alters components of the homogenate playing a major role in nitroxide decay, thus substantially modifying the kinetics of the process.
Effects of ultrasound irradiation on the properties of biological homogenates
MONTI, ELENA CATERINA
1997-01-01
Abstract
The effects induced in biological samples by free radicals generated during short periods (⩽ 5 min) of ultrasound irradiation have been investigated by following the decay kinetics of the electron paramagnetic resonance signal of the piperidine nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) in rat heart homogenates. Different kinetic models have been evaluated in order to identify the reactions involved in nitroxide decay. The results obtained indicate that sonication, however short its duration, significantly alters components of the homogenate playing a major role in nitroxide decay, thus substantially modifying the kinetics of the process.
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