Organ-specific autoimmunity frequently affects the endocrine system, including pancreatic islets. Type 1 diabetes mellitus (T1D) derives from the autoimmune destruction of insulin-secreting β-cells that is triggered by environmental factors (1, 2). Genetic predisposition accounts for 36–50% of disease susceptibility as demonstrated in monozygotic twin studies (3–5). Approximately 90% of new cases lack a family history of T1D indicating a large contribution of exogenous factors to pathogenesis. A variety of associations with viral infections have been reported for human diabetes including rubella, mumps, and cytomegalovirus. However, among investigated agents, human enteroviruses (HEVs) appear to play a prominent role (1).

Enteroviruses and causality of type 1 diabetes: how close we are?

BAJ, ANDREINA
Secondo
;
MACCARI, GIUSEPPE;SALVATONI, ALESSANDRO
Penultimo
;
TONIOLO, ANTONIO
Ultimo
2012-01-01

Abstract

Organ-specific autoimmunity frequently affects the endocrine system, including pancreatic islets. Type 1 diabetes mellitus (T1D) derives from the autoimmune destruction of insulin-secreting β-cells that is triggered by environmental factors (1, 2). Genetic predisposition accounts for 36–50% of disease susceptibility as demonstrated in monozygotic twin studies (3–5). Approximately 90% of new cases lack a family history of T1D indicating a large contribution of exogenous factors to pathogenesis. A variety of associations with viral infections have been reported for human diabetes including rubella, mumps, and cytomegalovirus. However, among investigated agents, human enteroviruses (HEVs) appear to play a prominent role (1).
2012
Diabetese; autoimmunity; virus; etiology; prevention
Diaz Horta, O; Baj, Andreina; Maccari, Giuseppe; Salvatoni, Alessandro; Toniolo, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1763500
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