Aims: The matrix-induced autologous chondrocyte implantation (MACI) is a tissue engineering technique which requires the use of a collagen membrane on which the cultured chondrocytes are seeded. We report the arthroscopic MACI technique for the treatment of chondral defects interesting lateral tibial plate of the knee. Methods: The implantation procedure was performed on two male patients affected by traumatic chondral lesions, sized respectly 2.5 and 2 cm2. The operations were performed through traditional artrhoscopic portals and the seeded membrane was fixed with fibrin glue. Clinical-functional evaluation was performed according to ICRS score, modified Cincinnati knee score, IKDC, Lysholm II and Tegner scales. MRIs (FSE Fat-Sat T2, SE T1, GRE T2) were taken 6, 12 and 24 months postoperatively. Results: No complications were observed in the postoperative period. After two year all the clinical scores were improved in both patients. MRI showed filling of the defects with hyaline-like tissue with reduction of subchondral bone edema and restoration of a regular articular surface. Conclusions: Even though the MACI technique is mostly performed with an open procedure, the site of these lesions could not be reached without sacrifying tendinous and ligamentous structures of the knee. The arthroscopic approach allowed to achieve an optimal view of the lesion and appeared the best solution for these patients. The use of fibrin glue for fixating the seeded membrane has made possible to perform the procedure arthroscopically in a simple and safe way. No specifically designed instruments were used in these cases. The size of these defects was too large for bone marrow stimulation techniques and/or osteochondral grafts to be successful. The development of dedicated instruments for arthroscopic MACI will probably allow to improve and simplify the surgical procedure.

Arthroscopic autologous chondrocyte implantation for the treatment of a chondral defects in the tibial plateau of the knee.

RONGA, MARIO;CHERUBINO, PAOLO
2004-01-01

Abstract

Aims: The matrix-induced autologous chondrocyte implantation (MACI) is a tissue engineering technique which requires the use of a collagen membrane on which the cultured chondrocytes are seeded. We report the arthroscopic MACI technique for the treatment of chondral defects interesting lateral tibial plate of the knee. Methods: The implantation procedure was performed on two male patients affected by traumatic chondral lesions, sized respectly 2.5 and 2 cm2. The operations were performed through traditional artrhoscopic portals and the seeded membrane was fixed with fibrin glue. Clinical-functional evaluation was performed according to ICRS score, modified Cincinnati knee score, IKDC, Lysholm II and Tegner scales. MRIs (FSE Fat-Sat T2, SE T1, GRE T2) were taken 6, 12 and 24 months postoperatively. Results: No complications were observed in the postoperative period. After two year all the clinical scores were improved in both patients. MRI showed filling of the defects with hyaline-like tissue with reduction of subchondral bone edema and restoration of a regular articular surface. Conclusions: Even though the MACI technique is mostly performed with an open procedure, the site of these lesions could not be reached without sacrifying tendinous and ligamentous structures of the knee. The arthroscopic approach allowed to achieve an optimal view of the lesion and appeared the best solution for these patients. The use of fibrin glue for fixating the seeded membrane has made possible to perform the procedure arthroscopically in a simple and safe way. No specifically designed instruments were used in these cases. The size of these defects was too large for bone marrow stimulation techniques and/or osteochondral grafts to be successful. The development of dedicated instruments for arthroscopic MACI will probably allow to improve and simplify the surgical procedure.
Ronga, Mario; Bulgheroni, P; Grassi, Fa; Cherubino, Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1793531
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