Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.

Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial

RASPANTI, MARIO;
2014-01-01

Abstract

Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.
2014
AFM; Collagen; Lactose; Lectins; Neoglycosylation; Reductive amination
Russo, L.; Gautieri, A.; Raspanti, Mario; Taraballi, F.; Nicotra, F.; Vesentini, S.; Cipolla, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1905324
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