Objective: Data from several centers worldwide have demonstrated that transnasal endoscopic surgery performed with or without a transcranial approach is capable of achieving radical resection of selected sinonasal malignancies. We report our experience with endoscopic management of sinonasal cancers, with emphasis on naso-ethmoidal malignancies encroaching on the anterior skull base. Methods: Major series reporting results concerning the endoscopic endonasal approach with or without craniectomy for treatment of sinonasal and anterior skull base cancers were reviewed. Preoperative work-up, indications and exclusion criteria, surgical techniques, postoperative management, and adjuvant therapy are reported. Results: In the 2 largest series analyzed, the most common malignancies were adenocarcinoma (28%), olfactory neuroblastoma (14.5%), and squamous cell carcinoma (13.5%). The 5-year disease-specific survival rate ranged from 81.9%-87%, with no major differences in the mean follow-up time (34.1 months vs. 37 months). Conclusions: Endoscopic endonasal resection performed with or without a transcranial approach, when properly planned and in expert hands, has an accepted role with precise indications in the surgeon's armamentarium for the treatment of sinonasal and skull base malignancies.

Endoscopic endonasal surgery for malignancies of the anterior cranial base

CASTELNUOVO, PAOLO GIOCONDO MARIA;BATTAGLIA, PAOLO;TOMEI, GIUSTINO;LOCATELLI, DAVIDE;BIGNAMI, MAURIZIO;TURRI ZANONI, MARIO
2014-01-01

Abstract

Objective: Data from several centers worldwide have demonstrated that transnasal endoscopic surgery performed with or without a transcranial approach is capable of achieving radical resection of selected sinonasal malignancies. We report our experience with endoscopic management of sinonasal cancers, with emphasis on naso-ethmoidal malignancies encroaching on the anterior skull base. Methods: Major series reporting results concerning the endoscopic endonasal approach with or without craniectomy for treatment of sinonasal and anterior skull base cancers were reviewed. Preoperative work-up, indications and exclusion criteria, surgical techniques, postoperative management, and adjuvant therapy are reported. Results: In the 2 largest series analyzed, the most common malignancies were adenocarcinoma (28%), olfactory neuroblastoma (14.5%), and squamous cell carcinoma (13.5%). The 5-year disease-specific survival rate ranged from 81.9%-87%, with no major differences in the mean follow-up time (34.1 months vs. 37 months). Conclusions: Endoscopic endonasal resection performed with or without a transcranial approach, when properly planned and in expert hands, has an accepted role with precise indications in the surgeon's armamentarium for the treatment of sinonasal and skull base malignancies.
2014
http://www.sciencedirect.com/science/article/pii/S1878875014006810
Cranio-endoscopic approach; Craniofacial resection; Endoscopic endonasal approach; Sinonasal cancers; Skull base reconstruction; Skull base surgery
Castelnuovo, PAOLO GIOCONDO MARIA; Battaglia, Paolo; Turri Zanoni, M; Tomei, Giustino; Locatelli, Davide; Bignami, Maurizio; Bolzoni Villaret, A.; Nicolai, P.; TURRI ZANONI, Mario
File in questo prodotto:
File Dimensione Formato  
castelnuovo world neurosurg 2014.pdf

non disponibili

Tipologia: Altro materiale allegato
Licenza: DRM non definito
Dimensione 3.09 MB
Formato Adobe PDF
3.09 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1990721
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 81
  • ???jsp.display-item.citation.isi??? 69
social impact