We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients.
Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions
PIARULLI, UMBERTO;
2015-01-01
Abstract
We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
OBC-2015-2570-Piarulli.pdf
accesso aperto
Descrizione: Articolo Principale
Tipologia:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
539.79 kB
Formato
Adobe PDF
|
539.79 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
