Background: Despite depressive disorders being very common there has been little research to guide primary care physicians on the choice of treatment for patients with mild to moderate depression. Aims: To evaluate the efficacy of interpersonal counselling compared with selective serotonin reuptake inhibitors (SSRIs), in primary care attenders with major depression and to identify moderators of treatment outcome. Method: A randomised controlled trial in nine centres (DEPICS, Australian New Zealand Clinical Trials Registry number: ACTRN12608000479303). The primary outcome was remission of the depressive episode (defined as a Hamilton Rating Scale for Depression score ≤7 at 2 months). Daily functioning was assessed using the Work and Social Adjustment Scale. Logistic regression models were used to identify moderators of treatment outcome. Results: The percentage of patients who achieved remission at 2 months was significantly higher in the interpersonal counselling group compared with the SSRI group (58.7% v. 45.1%, P = 0.021). Five moderators of treatment outcome were found: depression severity, functional impairment, anxiety comorbidity, previous depressive episodes and smoking habit. Conclusions: We identified some patient characteristics predicting a differential outcome with pharmacological and psychological interventions. Should our results be confirmed in future studies, these characteristics will help clinicians to define criteria for first-line treatment of depression targeted to patients' characteristics.

Moderators of remission with interpersonal counselling or drug treatment in primary care patients with depression: Randomised controlled trial

Baranzini, F.;Bortolaso, P.;Callegari, C.;Vender, S.;
2014-01-01

Abstract

Background: Despite depressive disorders being very common there has been little research to guide primary care physicians on the choice of treatment for patients with mild to moderate depression. Aims: To evaluate the efficacy of interpersonal counselling compared with selective serotonin reuptake inhibitors (SSRIs), in primary care attenders with major depression and to identify moderators of treatment outcome. Method: A randomised controlled trial in nine centres (DEPICS, Australian New Zealand Clinical Trials Registry number: ACTRN12608000479303). The primary outcome was remission of the depressive episode (defined as a Hamilton Rating Scale for Depression score ≤7 at 2 months). Daily functioning was assessed using the Work and Social Adjustment Scale. Logistic regression models were used to identify moderators of treatment outcome. Results: The percentage of patients who achieved remission at 2 months was significantly higher in the interpersonal counselling group compared with the SSRI group (58.7% v. 45.1%, P = 0.021). Five moderators of treatment outcome were found: depression severity, functional impairment, anxiety comorbidity, previous depressive episodes and smoking habit. Conclusions: We identified some patient characteristics predicting a differential outcome with pharmacological and psychological interventions. Should our results be confirmed in future studies, these characteristics will help clinicians to define criteria for first-line treatment of depression targeted to patients' characteristics.
2014
http://bjp.rcpsych.org/content/204/2/144.full.pdf+html
Activities of Daily Living; Adult; Anxiety; Depressive Disorder, Major; Effect Modifier, Epidemiologic; Female; Humans; Intention to Treat Analysis; Logistic Models; Male; Middle Aged; Outcome Assessment (Health Care); Patient Selection; Practice Guidelines as Topic; Primary Health Care; Psychiatric Status Rating Scales; Psychotherapy, Brief; Remission Induction; Serotonin Uptake Inhibitors; Severity of Illness Index; Smoking; Social Adjustment; Counseling
Menchetti, M.; Rucci, P.; Bortolotti, B.; Bombi, A.; Scocco, P.; Kraemer, H. C.; Berardi, D.; Luciano, C.; Lia, L.; Manganaro, D.; Magnani, M.; Nespeca, C.; Succu, M.; Bellino, S.; Bogetto, F.; Zizza, M.; Colombini, N.; Rigatelli, M.; Simoni, E.; Tedeschin, E.; Baranzini, F.; Bortolaso, P.; Callegari, C.; Diurni, M.; Vender, S.; Martinelli, V.; Politi, P.; Sciarini, P.; Piselli, M.; Quartesan, R.; Bellomo, A.; De Salvia, M.; Ferretti, M.; Iuso, S.; Petito, A.; Affatati, V.; Todarello, O.; Carpiniello, B.; Contu, C.; Pinna, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2020742
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