The study shows that modification of the DIPSS during follow-up of PMF patients may also predict different risks of blast phase (BP). Patients belonging to the higher risk categories have a notable 7.8-fold and 24.9-fold higher risk of developing BP comparing to those who continue to fit in low-risk category. As BP evolution implies a dismal outcome, this observation recommends to approach patients with higher DIPSS categories for intensive or investigative treatments.
Dynamic International Prognostic Scoring System (DIPSS) predicts progression to acute myeloid leukemia in primary myelofibrosis.
PASSAMONTI, FRANCESCO;
2010-01-01
Abstract
The study shows that modification of the DIPSS during follow-up of PMF patients may also predict different risks of blast phase (BP). Patients belonging to the higher risk categories have a notable 7.8-fold and 24.9-fold higher risk of developing BP comparing to those who continue to fit in low-risk category. As BP evolution implies a dismal outcome, this observation recommends to approach patients with higher DIPSS categories for intensive or investigative treatments.
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