We analyzed telomere lenght in a cohort of MPN patients in order to investigate its relationship with biological and clinical parameters. Patients with MPN present shortened telomeres irrespective of their JAK2 or MPL mutational status, implying that different molecular mechanisms may affect stem cells in the same way, and suggest that telomere assessment may be of potential diagnostic value in the work up of suspected MPN.
Flow-FISH evaluation of telomere length in Philadelphia-negative myeloproliferative neoplasms.
PASSAMONTI, FRANCESCO
2011-01-01
Abstract
We analyzed telomere lenght in a cohort of MPN patients in order to investigate its relationship with biological and clinical parameters. Patients with MPN present shortened telomeres irrespective of their JAK2 or MPL mutational status, implying that different molecular mechanisms may affect stem cells in the same way, and suggest that telomere assessment may be of potential diagnostic value in the work up of suspected MPN.
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