This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).
Autori: | |
Data di pubblicazione: | 2007 |
Titolo: | Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease |
Rivista: | BRITISH JOURNAL OF HAEMATOLOGY |
Digital Object Identifier (DOI): | 10.1111/j.1365-2141.2006.06437.x |
Codice identificativo ISI: | WOS:000243298200015 |
Codice identificativo Scopus: | 2-s2.0-33845894185 |
Codice identificativo Pubmed: | 17233821 |
Parole Chiave: | nodal marginal zone lymphoma; low-grade non-Hodgkin lymphoma; marginal zone; prognosis; hepatitis C virus. |
Appare nelle tipologie: | Articolo su Rivista |
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