Background Chronic rhinosinusitis (CRS) is a frequent disease with a high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms (SNPs) within the TAS2R38 gene were pointed at as possible contributors to the complex gene-environment interactions in CRS. This hypothesis was supported by in vitro evidence of the protective effect exerted by the functional bitter taste receptor T2R38 on sinonasal mucosa, due to its role in innate immunity. The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype and CRS comorbidities and to assess whether the presence of a particular allele can be considered a prognostic marker. Methods Fifty-three CRS patients and thirty-nine healthy individuals were genotyped at the TAS2R38 locus. CRS patients were treated by endoscopic sinus surgery and medical therapies and subdivided in “recalcitrant” and “healed”, depending on the clinical outcome, assessed by internationally accepted scoring systems. Chi-square analyses were used to assess the effect of genotype on CRS and CRS-related comorbidities. Results The distribution of the different genotypes at the TAS2R38 locus was not significantly different between recalcitrant CRS patients, healed CRS patients and controls (χ2[10] = 2.75, p = 0,99). Besides, no associations were found between the different genotypes at the TAS2R38 locus and CRS-related comorbidities. Conclusions No association was found between TAS2R38 alleles or genotypes and CRS, thus questioning its real contribution to CRS susceptibility. Further studies on larger cohorts are needed to verify these findings also in vivo and to shed light on the role of bitter taste receptors in CRS.
TAS2R38 taste receptor gene and chronic rhinosinusitis: a bitter ending
GALLO, STEFANIA;GROSSI, SARAH;BINELLI, GIORGIO PIETRO MARIO;CINQUETTI, RAFFAELLA;CASTELNUOVO, PAOLO GIOCONDO MARIA;CAMPOMENOSI, PAOLA
2015-01-01
Abstract
Background Chronic rhinosinusitis (CRS) is a frequent disease with a high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms (SNPs) within the TAS2R38 gene were pointed at as possible contributors to the complex gene-environment interactions in CRS. This hypothesis was supported by in vitro evidence of the protective effect exerted by the functional bitter taste receptor T2R38 on sinonasal mucosa, due to its role in innate immunity. The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype and CRS comorbidities and to assess whether the presence of a particular allele can be considered a prognostic marker. Methods Fifty-three CRS patients and thirty-nine healthy individuals were genotyped at the TAS2R38 locus. CRS patients were treated by endoscopic sinus surgery and medical therapies and subdivided in “recalcitrant” and “healed”, depending on the clinical outcome, assessed by internationally accepted scoring systems. Chi-square analyses were used to assess the effect of genotype on CRS and CRS-related comorbidities. Results The distribution of the different genotypes at the TAS2R38 locus was not significantly different between recalcitrant CRS patients, healed CRS patients and controls (χ2[10] = 2.75, p = 0,99). Besides, no associations were found between the different genotypes at the TAS2R38 locus and CRS-related comorbidities. Conclusions No association was found between TAS2R38 alleles or genotypes and CRS, thus questioning its real contribution to CRS susceptibility. Further studies on larger cohorts are needed to verify these findings also in vivo and to shed light on the role of bitter taste receptors in CRS.
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