A systemic administration of L19mTNFa selectively targets the tumor vasculature, and in combination with melphalan is able to induce a long-lasting therapeutic response and immune T cell memory in different murine tumor models. The combined treatment was exploited to determine the role of DC, NK and macrophages in WEHI-164 and C51 tumors. A systemic administration of L19mTNFa selectively targets the tumor vasculature, and in combination with melphalan is able to induce a long-lasting therapeutic response and immune T cell memory in different murine tumor models. The combined treatment was exploited to determine the role of DC, NK and macrophages in WEHI-164 and C51 tumors.
Early DC and NK cell activation during anticancer therapeutic response induced by TNFa tumor vessel delivery and melphalan
NOONAN, DOUGLAS;MORTARA, LORENZO
2015-01-01
Abstract
A systemic administration of L19mTNFa selectively targets the tumor vasculature, and in combination with melphalan is able to induce a long-lasting therapeutic response and immune T cell memory in different murine tumor models. The combined treatment was exploited to determine the role of DC, NK and macrophages in WEHI-164 and C51 tumors. A systemic administration of L19mTNFa selectively targets the tumor vasculature, and in combination with melphalan is able to induce a long-lasting therapeutic response and immune T cell memory in different murine tumor models. The combined treatment was exploited to determine the role of DC, NK and macrophages in WEHI-164 and C51 tumors.
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