Natural killer (NK) cells are lymphoid cells involved in tumor recognition and eradication. NK activity is impaired in cancer patients and in non-small cell lung cancer showed a pro-angiogenic phenotype and function. We investigated whether NK cells infiltrating malignant pleural effusions (mPE) from subjects with primary or metastatic tumors are able to acquire pro-angiogenic features. NK cells from mPE display pro-angiogenic features and mPE-CM was able to polarize in vitro healthy PB NK cells towards the pro-angiogenic CD56brightCD16- NK subset, suggesting that in the mPE milieu, diverse soluble factors are able to skew cytotoxic NK cells into pro-tumor, pro-angiogenic NK cells.

Natural killer cells from malignant pleural effusions show a decidual-like, pro-angiogenic phenotype

Bruno, A.;IMPERATORI, ANDREA SELENITO;DOMINIONI, LORENZO;NOONAN, DOUGLAS;MORTARA, LORENZO
2015-01-01

Abstract

Natural killer (NK) cells are lymphoid cells involved in tumor recognition and eradication. NK activity is impaired in cancer patients and in non-small cell lung cancer showed a pro-angiogenic phenotype and function. We investigated whether NK cells infiltrating malignant pleural effusions (mPE) from subjects with primary or metastatic tumors are able to acquire pro-angiogenic features. NK cells from mPE display pro-angiogenic features and mPE-CM was able to polarize in vitro healthy PB NK cells towards the pro-angiogenic CD56brightCD16- NK subset, suggesting that in the mPE milieu, diverse soluble factors are able to skew cytotoxic NK cells into pro-tumor, pro-angiogenic NK cells.
2015
Zanellato, S.; Bruno, A.; Cattoni, M.; Bassani, B.; Imperatori, ANDREA SELENITO; Dominioni, Lorenzo; Albini, A.; Noonan, Douglas; Mortara, Lorenzo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2027333
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