We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019).
Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia
FERRARI, MARCOFormal Analysis
;BORTOLASO, PAOLA
Methodology
;CALLEGARI, CAMILLASupervision
;POLONI, NICOLAData Curation
;LECCHINI, SERGIOConceptualization
;VENDER, SIMONEValidation
;MARINO, FRANCAWriting – Original Draft Preparation
;COSENTINO, MARCOWriting – Review & Editing
2012-01-01
Abstract
We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019).
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
association between cyp1a2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia. psychiatry research.pdf
non disponibili
Descrizione: Articolo principale
Tipologia:
Versione Editoriale (PDF)
Licenza:
Copyright dell'editore
Dimensione
305.7 kB
Formato
Adobe PDF
|
305.7 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
