We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019). © 2012 Elsevier Ireland Ltd.

Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia

FERRARI, MARCO
Formal Analysis
;
BORTOLASO, PAOLA
Methodology
;
CALLEGARI, CAMILLA
Supervision
;
POLONI, NICOLA
Data Curation
;
LECCHINI, SERGIO
Conceptualization
;
VENDER, SIMONE
Validation
;
MARINO, FRANCA
Writing – Original Draft Preparation
;
COSENTINO, MARCO
Writing – Review & Editing
2012-01-01

Abstract

We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019). © 2012 Elsevier Ireland Ltd.
Cytochrome; Pharmacogenetic; Schizophrenia; Adult; Alleles; Antipsychotic Agents; Clozapine; Cytochrome P-450 CYP1A2; Female; Gene Frequency; Genetic Association Studies; Humans; Male; Middle Aged; Schizophrenia; Polymorphism, Genetic; Psychiatry and Mental Health; Biological Psychiatry
Ferrari, Marco; Bolla, Emilio; Bortolaso, Paola; Callegari, Camilla; Poloni, Nicola; Lecchini, Sergio; Vender, Simone; Marino, Franca; Cosentino, Marco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2051870
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