Perimidines are extensively studied for their different therapeutic properties, including antiulcer, antifungal, antimicrobial, immunosuppressive and anticancer activities. Moreover, their heterocyclic structure embodies the naphthalene moiety, exploited in bio-imaging and biomolecules staining due to its high fluorescence. In this work we present the spectroscopic characterization of a family of perimidine derivatives, in order to obtain information potentially useful for the design of compounds combining biological activity and detectable fluorescence in physiological environment.

Fluorescence studies on 2-(het)aryl perimidine derivatives

LAMPERTI, MARCO;MASPERO, ANGELO;CIMINO, ALESSANDRO;PALMISANO, GIOVANNI;NARDO, LUCA
2016

Abstract

Perimidines are extensively studied for their different therapeutic properties, including antiulcer, antifungal, antimicrobial, immunosuppressive and anticancer activities. Moreover, their heterocyclic structure embodies the naphthalene moiety, exploited in bio-imaging and biomolecules staining due to its high fluorescence. In this work we present the spectroscopic characterization of a family of perimidine derivatives, in order to obtain information potentially useful for the design of compounds combining biological activity and detectable fluorescence in physiological environment.
Drug-DNA binding; Fluorescence; Perimidines; Theranostics; Biophysics; Biochemistry; Chemistry (all); Atomic and Molecular Physics, and Optics; Condensed Matter Physics
Giani, Arianna Maria; Lamperti, Marco; Maspero, Angelo; Cimino, Alessandro; Negri, Roberto; Giovenzana, Giovanni Battista; Palmisano, Giovanni; Nardo, Luca
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11383/2055069
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