Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

A European Respiratory Society technical standard: exhaled biomarkers in lung disease

SPANEVELLO, ANTONIO;
2017-01-01

Abstract

Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.
2017
http://erj.ersjournals.com/content/erj/49/4/1600965.full.pdf
VOLATILE ORGANIC-COMPOUNDS; BREATH CONDENSATE PH; NASAL NITRIC-OXIDE; OBSTRUCTIVE PULMONARY-DISEASE; PRIMARY CILIARY DYSKINESIA; EXTENDED NO ANALYSIS; MAGNETIC-RESONANCE-SPECTROSCOPY; MASS-SPECTROMETRIC ANALYSIS; SLEEP-APNEA SYNDROME; ELECTRONIC NOSE
Horváth, Ildiko; Barnes, Peter J; Loukides, Stelios; Sterk, Peter J; Högman, Marieann; Olin, Anna Carin; Amann, Anton; Antus, Balazs; Baraldi, Eugenio; Bikov, Andras; Boots, Agnes W; Bos, Lieuwe D; Brinkman, Paul; Bucca, Caterina; Carpagnano, Giovanna E; Corradi, Massimo; Cristescu, Simona; de Jongste, Johan C; Dinh Xuan, Anh Tuan; Dompeling, Edward; Fens, Niki; Fowler, Stephen; Hohlfeld, Jens M; Holz, Olaf; Jöbsis, Quirijn; Van De Kant, Kim; Knobel, Hugo H; Kostikas, Konstantinos; Lehtimäki, Lauri; Lundberg, Jon; Montuschi, Paolo; Van Muylem, Alain; Pennazza, Giorgio; Reinhold, Petra; Ricciardolo, Fabio L. M; Rosias, Philippe; Santonico, Marco; van der Schee, Marc P; van Schooten, Frederik Jan; Spanevello, Antonio; Tonia, Thomy; Vink, Teunis J.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2062571
 Attenzione

L'Ateneo sottopone a validazione solo i file PDF allegati

Citazioni
  • ???jsp.display-item.citation.pmc??? 176
  • Scopus 426
  • ???jsp.display-item.citation.isi??? 390
social impact