The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. Design and methods One-hundred-ninety-six consecutive patients (152 women; mean age 51±13 years) with visceral obesity [mean body weight 103±20 Kg, mean waist circumference (WC) 119±13 cm] were enrolled at the Obesity Outpatient Clinic of the University of Insubria in Varese. Anthropometric measurements were recorded. Laboratory tests, including vitamin D [25(OH)D)], fasting blood glucose (FBG), lipid profile, liver and kidney function tests were assessed. Vitamin D status was defined according to the European Society of Endocrinology guidelines, MetS to the 2009 harmonized definition. An inverse association emerged among [25(OH)D], body mass index (BMI) (p=0.001) and WC (all p=0.003). Serum [25(OH)D] levels were inversely related to FBG and systolic blood pressure (SBP) (respectively, p=0.01 and 0.02). Median serum [25(OH)D] levels were 13.3 ng/ml (CI 95% 12;15) in MetS and 16 ng/ml (CI 95% 14;18) (p=0.01) in non-MetS patients. Among patients with MetS, lower [25(OH)D] concentrations were related to higher risk of hypertension (HT) [Odds Ratio (OR) 1.7, CI 95%, 0.7;4] and hyperglycemia (IFG)/ type 2 diabetes (OR 5.5, CI 95% 2;14). Vitamin D status and MetS are inversely correlated in visceral obesity, particularly with regard to glucose homeostasis and BP. More extensive studies are required to investigate the potential for causality.

Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?

PIANTANIDA, ELIANA ANGELA ROSA;GALLO, DANIELA;VERONESI, GIOVANNI;DOZIO, EUGENIA LUIGIA MARIA;TROTTI, EUGENIA;IPPOLITO, SILVIA;SABATINO, JESSICA;Tanda, Maria Laura;TONIOLO, ANTONIO;FERRARIO, MARCO MARIO ANGELO;BARTALENA, LUIGI
2017-01-01

Abstract

The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. Design and methods One-hundred-ninety-six consecutive patients (152 women; mean age 51±13 years) with visceral obesity [mean body weight 103±20 Kg, mean waist circumference (WC) 119±13 cm] were enrolled at the Obesity Outpatient Clinic of the University of Insubria in Varese. Anthropometric measurements were recorded. Laboratory tests, including vitamin D [25(OH)D)], fasting blood glucose (FBG), lipid profile, liver and kidney function tests were assessed. Vitamin D status was defined according to the European Society of Endocrinology guidelines, MetS to the 2009 harmonized definition. An inverse association emerged among [25(OH)D], body mass index (BMI) (p=0.001) and WC (all p=0.003). Serum [25(OH)D] levels were inversely related to FBG and systolic blood pressure (SBP) (respectively, p=0.01 and 0.02). Median serum [25(OH)D] levels were 13.3 ng/ml (CI 95% 12;15) in MetS and 16 ng/ml (CI 95% 14;18) (p=0.01) in non-MetS patients. Among patients with MetS, lower [25(OH)D] concentrations were related to higher risk of hypertension (HT) [Odds Ratio (OR) 1.7, CI 95%, 0.7;4] and hyperglycemia (IFG)/ type 2 diabetes (OR 5.5, CI 95% 2;14). Vitamin D status and MetS are inversely correlated in visceral obesity, particularly with regard to glucose homeostasis and BP. More extensive studies are required to investigate the potential for causality.
Diabetes; Metabolic syndrome; Obesity; Vitamin D;
Piantanida, ELIANA ANGELA ROSA; Gallo, Daniela; Veronesi, Giovanni; Dozio, EUGENIA LUIGIA MARIA; Trotti, Eugenia; Lai, Adriana; Ippolito, Silvia; Sabatino, Jessica; Tanda, Maria Laura; Toniolo, Antonio; Ferrario, MARCO MARIO ANGELO; Bartalena, Luigi
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2066359
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 13
social impact