IRIS - Institutional Research Information System
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi dell’Insubria.
IRInSubria - Institutional Repository Insubria
IRInSubria raccoglie, conserva, documenta e dissemina le informazioni sulla produzione scientifica dell'Università degli Studi dell’Insubria anche ai fini della valutazione della ricerca.
EnglishpH-sensitive polymersomes are produced from amphiphilic copolymers of the type mPEG-b-(PMMA-ran-PDMAEMA) obtained via ATRP, so that mPEG with molecular masses of 2k and 5kDa forms the corona of a hydrophobic double layer with 22â28% molar content in protonable DMAEMA. Vesicles obtained via dialysis were loaded with curcumin, 2-naphthole, paclitaxel (PTX) and ampicillin sodium salt, and the release kinetics of the latter studied via UV-vis spectrometry as a function of pH. Overall, the release profiles clearly indicated a dopant-sensitive kinetics and, likely, mechanism depending on molecule-copolymer interactions. Infrared spectrometry highlighted the formation of hydrogen bonds and salt bridges that may be responsible for these findings; support for the formation of the latter are obtained comparing the IR spectrum for ampicillin doped-vesicles with the anharmonic vibrational transition of model salt bridges. Importantly, DLS data indicated that our vesicles appeared to remain stable even at pH 4.4 after 48Â h and completely releasing ampicillin. The release profiles of co-loaded curcumin/PTX with ampicillin also suggest that desorption rates of water-soluble species can be modulated by the presence of hydrophobic molecules in the double layer, at least at pH 7.4 and 6.4.
| Autori: | IZZO, LORELLA (Corresponding) |
| Data di pubblicazione: | 2017 |
| Titolo: | Impact of intermolecular drug-copolymer interactions on size and drug release kinetics from pH-responsive polymersomes |
| Rivista: | SUPRAMOLECULAR CHEMISTRY |
| Digital Object Identifier (DOI): | 10.1080/10610278.2017.1377836 |
| Codice identificativo ISI: | WOS:000415626000004 |
| Codice identificativo Scopus: | 2-s2.0-85029717104 |
| Parole Chiave: | drug release kinetic; intermolecular interactions; pH-sensitive copolymer; Polymersomes; Chemistry (all) |
| URL: | http://www.tandf.co.uk/journals/titles/10610278.html |
| Appare nelle tipologie: | Articolo su Rivista |
File in questo prodotto:
http://hdl.handle.net/11383/2066509
Copyright © 2019