Multiscale polymeric composites combining a biodegradable matrix with low cost and biocompatible hybrid nanocarriers promise to supply a new generation of multipurpose devices for drug delivery. The aim of this work was to investigate the release mechanisms of sodium benzoate (NaBz) from halloysite nanotubes (HNTs) embedded in a biodegradable polymer matrix (poly(ϵ-caprolactone)). To that purpose, different amounts of NaBz molecules were successfully incorporated into HNTs using a simple environmentally friendly procedure. The resulting HNT-NaBz nano-hybrids were then incorporated into a poly(ϵ-caprolactone) matrix by high energy ball milling at ambient temperature and in dry conditions. Analysis of the resulting composites showed important effects of the HNT-NaBz nano-hybrids on the thermal and mechanical properties. Controlled drug release, followed by UV spectrophotometry, was also found to be dependent on the HNT-NaBz relative fractions. Experimental data were thus analyzed using a modified Gallagher − Corrigan model and correlated with the nano-hybrid morphologies. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry

Controlled release mechanisms of sodium benzoate from a biodegradable polymer and halloysite nanotube composite

Izzo, L.;
2017-01-01

Abstract

Multiscale polymeric composites combining a biodegradable matrix with low cost and biocompatible hybrid nanocarriers promise to supply a new generation of multipurpose devices for drug delivery. The aim of this work was to investigate the release mechanisms of sodium benzoate (NaBz) from halloysite nanotubes (HNTs) embedded in a biodegradable polymer matrix (poly(ϵ-caprolactone)). To that purpose, different amounts of NaBz molecules were successfully incorporated into HNTs using a simple environmentally friendly procedure. The resulting HNT-NaBz nano-hybrids were then incorporated into a poly(ϵ-caprolactone) matrix by high energy ball milling at ambient temperature and in dry conditions. Analysis of the resulting composites showed important effects of the HNT-NaBz nano-hybrids on the thermal and mechanical properties. Controlled drug release, followed by UV spectrophotometry, was also found to be dependent on the HNT-NaBz relative fractions. Experimental data were thus analyzed using a modified Gallagher − Corrigan model and correlated with the nano-hybrid morphologies. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry
2017
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85007500738&doi=10.1002%2fpi.5309&partnerID=40&md5=8cbbfdcd9924149151c48fcc7599a81f
Gorrasi, G.; Attanasio, G.; Izzo, L.; Sorrentino, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2066532
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