Glycopeptide antibiotics are drugs of last resort for treating severe infections caused by multi-drug resistant Gram-positive pathogens. First-generation glycopeptides (vancomycin and teicoplanin) are produced by soil-dwelling actinomycetes. Second-generation glycopeptides (dalbavancin, oritavancin, and telavancin) are semi-synthetic derivatives of the progenitor natural products. Herein, we cover past and present biotechnological approaches for searching for and producing old and new glycopeptide antibiotics. We review the strategies adopted to increase microbial production (from classical strain improvement to rational genetic engineering), and the recent progress in genome mining, chemoenzymatic derivatization, and combinatorial biosynthesis for expanding glycopeptide chemical diversity and tackling the never-ceasing evolution of antibiotic resistance.

Old and new glycopeptide antibiotics: From product to gene and back in the post-genomic era

Marcone, Giorgia Letizia;Binda, Elisa;Berini, Francesca;Marinelli, Flavia
2018-01-01

Abstract

Glycopeptide antibiotics are drugs of last resort for treating severe infections caused by multi-drug resistant Gram-positive pathogens. First-generation glycopeptides (vancomycin and teicoplanin) are produced by soil-dwelling actinomycetes. Second-generation glycopeptides (dalbavancin, oritavancin, and telavancin) are semi-synthetic derivatives of the progenitor natural products. Herein, we cover past and present biotechnological approaches for searching for and producing old and new glycopeptide antibiotics. We review the strategies adopted to increase microbial production (from classical strain improvement to rational genetic engineering), and the recent progress in genome mining, chemoenzymatic derivatization, and combinatorial biosynthesis for expanding glycopeptide chemical diversity and tackling the never-ceasing evolution of antibiotic resistance.
2018
Glycopeptide antibiotics; Vancomycin; Teicoplanin; A40926; Dalbavancin; Natural product screening; Strain improvement; Fermentation; Genetic engineering; Combinatorial biochemistry
Marcone, Giorgia Letizia; Binda, Elisa; Berini, Francesca; Marinelli, Flavia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2069323
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