Malonyl carba(dethia) N-decanoyl cysteamine methyl esters and novel acetoxymethyl esters were utilised as second-generation probes for polyketide intermediate capture. The use of these tools in vivo led to the characterisation of an almost complete set of biosynthetic intermediates from a modular assembly line, providing a first kinetic overview of intermediate processing leading to complex natural product formation

Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly

Silvia Gazzola
Membro del Collaboration Group
;
2016-01-01

Abstract

Malonyl carba(dethia) N-decanoyl cysteamine methyl esters and novel acetoxymethyl esters were utilised as second-generation probes for polyketide intermediate capture. The use of these tools in vivo led to the characterisation of an almost complete set of biosynthetic intermediates from a modular assembly line, providing a first kinetic overview of intermediate processing leading to complex natural product formation
2016
SYNTHETIC BIOLOGY; NATURAL-PRODUCT; CHEMICAL PROBES; SYNTHASE MODULE; INSIGHTS; PRODRUGS; ANTICANCER; COMPLEX; ACID; DRUG
Wilkening, Ina; Gazzola, Silvia; Riva, Elena; Parascandolo, James S.; Song, Lijiang; Tosin, Manuela
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2070542
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