Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF 3 substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF 3 species. We also implemented an in-flow protocol to improve the safety features of the process.
Metal-free alpha trifluoromethylselenolation of carbonyl derivatives under batch and flow conditions
Benincori, Tiziana
2019-01-01
Abstract
Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF 3 substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF 3 species. We also implemented an in-flow protocol to improve the safety features of the process.
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