The association between inferior vena cava filter (IVC) use and outcome in patients presenting with major bleeding during anticoagulation for venous thromboembolism (VTE) has not been thoroughly investigated. We used the RIETE registry to compare the 30-day outcomes (death, major re-bleeding or VTE recurrences) in VTE patients who bled during the first 3 months of therapy, regarding the insertion of an IVC filter. A propensity score matched (PSM) analysis was performed to adjust for potential confounders. From January 2001 to September 2016, 1065 VTE patients had major bleeding during the first 3 months of anticoagulation (gastrointestinal 370; intracranial 124). Of these, 122 patients (11%) received an IVC filter. Patients receiving a filter restarted anticoagulation later (median, 4 vs. 2 days) and at lower doses (95 ± 52 IU/kg/day vs. 104 ± 55 of low-molecular-weight heparin) than those not receiving a filter. During the first 30 days after bleeding (after excluding 246 patients who died within the first 24 h), 283 patients (27%) died, 63 (5.9%) had non-fatal re-bleeding and 19 (1.8%) had recurrent pulmonary embolism (PE). In PSM analysis, patients receiving an IVC filter (n = 122) had a lower risk for all-cause death (HR 0.49; 95% CI 0.31-0.77) or fatal bleeding (HR 0.16; 95% CI 0.07-0.49) and a similar risk for re-bleeding (HR 0.55; 95% CI 0.23-1.40) or PE recurrences (HR 1.57; 95% CI 0.38-6.36) than those not receiving a filter (n = 429). In VTE patients experiencing major bleeding during the first 3 months, use of an IVC filter was associated with reduced mortality rates.Clinical Trial Registration NCT02832245.

Vena cava filters in patients presenting with major bleeding during anticoagulation for venous thromboembolism

Lorenzo A.;Bucherini E.;Dentali F.;MAGGI, FABRIZIO;Mastroiacovo D.;TONELLO, DIEGO;
2019-01-01

Abstract

The association between inferior vena cava filter (IVC) use and outcome in patients presenting with major bleeding during anticoagulation for venous thromboembolism (VTE) has not been thoroughly investigated. We used the RIETE registry to compare the 30-day outcomes (death, major re-bleeding or VTE recurrences) in VTE patients who bled during the first 3 months of therapy, regarding the insertion of an IVC filter. A propensity score matched (PSM) analysis was performed to adjust for potential confounders. From January 2001 to September 2016, 1065 VTE patients had major bleeding during the first 3 months of anticoagulation (gastrointestinal 370; intracranial 124). Of these, 122 patients (11%) received an IVC filter. Patients receiving a filter restarted anticoagulation later (median, 4 vs. 2 days) and at lower doses (95 ± 52 IU/kg/day vs. 104 ± 55 of low-molecular-weight heparin) than those not receiving a filter. During the first 30 days after bleeding (after excluding 246 patients who died within the first 24 h), 283 patients (27%) died, 63 (5.9%) had non-fatal re-bleeding and 19 (1.8%) had recurrent pulmonary embolism (PE). In PSM analysis, patients receiving an IVC filter (n = 122) had a lower risk for all-cause death (HR 0.49; 95% CI 0.31-0.77) or fatal bleeding (HR 0.16; 95% CI 0.07-0.49) and a similar risk for re-bleeding (HR 0.55; 95% CI 0.23-1.40) or PE recurrences (HR 1.57; 95% CI 0.38-6.36) than those not receiving a filter (n = 429). In VTE patients experiencing major bleeding during the first 3 months, use of an IVC filter was associated with reduced mortality rates.Clinical Trial Registration NCT02832245.
2019
http://www.springer.com/italy/home?SGWID=6-102-70-173668106-0&changeHeader=true
Anticoagulants; Bleeding; Mortality; Vena cava filter; Venous thromboembolism
Mellado, M.; Trujillo-Santos, J.; Bikdeli, B.; Jimenez, D.; Nunez, M. J.; Ellis, M.; Marchena, P. J.; Vela, J. R.; Clara, A.; Moustafa, F.; Monreal, M.; Adarraga, M. D.; Aibar, M. A.; Alfonso, M.; Arcelus, J. I.; Ballaz, A.; Banos, P.; Barba, R.; Barron, M.; Bascunana, J.; Blanco-Molina, A.; Camon, A. M.; Carrasco, C.; Chasco, L.; Cruzs, A. J.; del Pozo, R.; del Toro, J.; Diaz-Pedroche, M. C.; Diaz-Peromingo, J. A.; Encabo, M.; Falga, C.; Fernandez-Aracil, C.; Fernandez-Capitan, C.; Fidalgo, M. A.; Font, C.; Font, L.; Furest, I.; Garcia, M. A.; Garcia-Bragado, F.; Garcia-Morillo, M.; Garcia-Raso, A.; Garcia-Sanchez, I.; Gavin, O.; Gomez, C.; Gomez, V.; Gonzalez, J.; Grau, E.; Guijarro, R.; Guirado, L.; Gutierrez, J.; Hernandez-Blasco, L.; Hernando, E.; Isern, V.; Jara-Palomares, L.; Jaras, M. J.; Jimenez, D.; Joya, M. D.; Lima, J.; Llamas, P.; Lobo, J. L.; Lopez-Jimenez, L.; Lopez-Reyes, R.; Lopez-Saez, J. B.; Lorente, M. A.; Lorenzo, A.; Loring, M.; Lumbierres, M.; Madridano, O.; Maestre, A.; Marchena, P. J.; Martin, M.; Martin-Martos, F.; Mellado, M.; Monreal, M.; Morales, M. V.; Nieto, J. A.; Nunez, M. J.; Olivares, M. C.; Otalora, S.; Otero, R.; Pedrajas, J. M.; Pellejero, G.; Perez-Ductor, C.; Peris, M. L.; Pons, I.; Porras, J. A.; Riera-Mestre, A.; Rivas, A.; Rodriguez-Davila, M. A.; Rodriguez-Galan, I.; Rosa, V.; Rubio, C. M.; Ruiz-Artacho, P.; Sahuquillo, J. C.; Sala-Sainz, M. C.; Samperiz, A.; Sanchez-Artola, B.; Sanchez-Martinez, R.; Sancho, T.; Soler, S.; Soto, M. J.; Surinach, J. M.; Tolosa, C.; Torres, M. I.; Trujillo-Santos, J.; Uresandi, F.; Usandizaga, E.; Valero, B.; Valle, R.; Vela, J.; Vidal, G.; Villalobos, A.; Xifre, B.; Vazquez, F. J.; Vilaseca, A.; Vanassche, T.; Vandenbriele, C.; Verhamme, P.; Yoo, H. H. B.; Wells, P.; Hirmerova, J.; Maly, R.; Salgado, E.; Benzidia, I.; Bertoletti, L.; Bura-Riviere, A.; Falvo, N.; Farge-Bancel, D.; Hij, A.; Merah, A.; Mahe, I.; Moustafa, F.; Quere, I.; Braester, A.; Brenner, B.; Ellis, M.; Tzoran, I.; Antonucci, G.; Bilora, F.; Bucherini, E.; Cattabiani, C.; Ciammaichella, M.; Dentali, F.; Di Micco, P.; Doddi, M.; Duce, R.; Giorgi-Pierfranceschi, M.; Grandone, E.; Imbalzano, E.; Lessiani, G.; Maggi, Fabrizio; Maida, R.; Mastroiacovo, D.; Pace, F.; Pesavento, R.; Poggio, R.; Prandoni, P.; Quintavalla, R.; Rocci, A.; Siniscalchi, C.; Tiraferri, E.; Tonello, Diego; Visona, A.; Zalunardo, B.; Gibietis, V.; Skride, A.; Vitola, B.; Zdraveska, M.; Bounameaux, H.; Calanca, L.; Fresa, M.; Mazzolai, L.; Bikdeli, B.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2083152
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