A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines has been developed through the regioselective cyclization of diols. Cyclization precursors have been obtained by the ring opening of com. available chiral epoxides under solid-liq. phase transfer catalysis conditions (SL-PTC).
A practical approach to the synthesis of enantiomerically pure 2,6-disubstituted morpholines under phase transfer catalysis conditions
F. Foschi;
2009-01-01
Abstract
A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines has been developed through the regioselective cyclization of diols. Cyclization precursors have been obtained by the ring opening of com. available chiral epoxides under solid-liq. phase transfer catalysis conditions (SL-PTC).
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