An efficient selective synthesis of methyl dithienyl-glycolates has been developed. The interest of this two steps protocol resides in the possibility of synthesized either methyl 2,2-dithienyl glycolate – the target intermediate for the preparation of anticholinergic agents – or its regio-isomer methyl 2,3-dithienyl glycolate – the most critical precursor of anticholinergic drug impurity.

Selective synthesis of methyl dithienyl-glycolates

Foschi, Francesca;Passarella, Daniele
2018-01-01

Abstract

An efficient selective synthesis of methyl dithienyl-glycolates has been developed. The interest of this two steps protocol resides in the possibility of synthesized either methyl 2,2-dithienyl glycolate – the target intermediate for the preparation of anticholinergic agents – or its regio-isomer methyl 2,3-dithienyl glycolate – the most critical precursor of anticholinergic drug impurity.
2018
Bromothiophene lithiation; dithienyl glycolate; muscarinic antagonist; COPD
Foschi, Francesca; Bonandi, Elisa; Mereu, Andrea; Pacchetti, Barbara; Gozzini, Davide; Passarella, Daniele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2086307
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